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I found it interesting what various authorities were saying about Conflicker. Symmantec said it was serious. McAfee said it was over hyped, but that you should not assume that you were safe. F-Secure said the thing would not cause any visible damage. Finally the USA Today said Conflicker was no small threat.
In general, I determined that you would be ok if your computer was up to date. You are better off if you are behind a firewall like most home users are. It would help if you had intrusion detection software such as ZoneAlarm installed and configured. You can help prevent infection by choosing strong passwords for Windows admin accounts, and by disabling autorun.
Initially there were reports that there may be as many as 15 million infections on April 1st. In retrospect, this seems to be more of an April Fools joke. The date came and went without incident. I wonder what was really behind all the hysteria. At least it got me to download the latest security patches from Microsoft for my Windows box.